Sympathetic dysregulation induced by postnatal intermittent hypoxia.
Marlusa Karlen-AmaranteIsabela de Paula LeirãoPedro L KatayamaEduardo ColombariPaloma G Bittencourt-SilvaMiguel F MenezesDaniel B ZoccalPublished in: Sleep (2023)
pCIH facilitates the vasoconstrictor sympathetic drive by mechanisms associated with enhanced firing activity and HIF-1α expression in ventromedullary pre-sympathetic neurons. This excessive sympathetic activity persists until adulthood resulting in high blood pressure levels and variability, which contribute to developing cardiovascular diseases.