Untargeted high-resolution plasma metabolomic profiling predicts outcomes in patients with coronary artery disease.

Anurag MehtaChang LiuAditi NayakAyman S TahhanYi-An KoDevinder S DhindsaJeong Hwan KimSalim Salim HayekLaurence S SperlingPuja K MehtaYan V SunKaran UppalDean P JonesArshed A Quyyumi

Published in: PloS one (2020)

Differential regulation of six metabolic pathways involved in myocardial energetics and systemic inflammation is independently associated with mortality in patients with CAD. A novel risk score consisting of representative metabolites is highly predictive of mortality.

Keyphrases

high resolution
cardiovascular events
mass spectrometry
risk factors
left ventricular
cross sectional
type diabetes
liquid chromatography
skeletal muscle
adipose tissue
insulin resistance
high resolution mass spectrometry
high speed