Effectiveness of vancomycin plus cloxacillin compared with vancomycin, cloxacillin and daptomycin single therapies in the treatment of methicillin-resistant and methicillin-susceptible Staphylococcus aureus in a rabbit model of experimental endocarditis.

Ximena CastañedaCristina García-De-la-MàriaOriol GaschJuan M PericàsDolors SoyMaria-Alejandra Cañas-PachecoCarlos FalcesJavier García-GonzálezMarta Hernández-MenesesBàrbara VidalManel AlmelaEduard QuintanaJose M TolosanaDavid FusterJaume LlopisAnders DahlAsuncion MorenoFrancesc MarcoJose M Mirónull null

Published in: The Journal of antimicrobial chemotherapy (2021)

Vancomycin plus cloxacillin proved synergistic and bactericidal activity against MRSA. Daptomycin was the most efficacious option against MSSA and similar to vancomycin plus cloxacillin against MRSA. In settings with high MRSA prevalence, vancomycin plus cloxacillin might be a good alternative for empirical therapy of S. aureus IE.

Keyphrases

methicillin resistant staphylococcus aureus
staphylococcus aureus
biofilm formation
randomized controlled trial
systematic review
risk factors
stem cells
bone marrow
combination therapy