The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance.
George I LambrouKyriaki HatziagapiouApostolos ZaravinosPublished in: International journal of molecular sciences (2020)
The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.
Keyphrases
- room temperature
- prostate cancer
- high glucose
- endothelial cells
- carbon dioxide
- systematic review
- poor prognosis
- stem cells
- cell death
- acute myeloid leukemia
- squamous cell carcinoma
- signaling pathway
- endoplasmic reticulum stress
- white matter
- cell proliferation
- long noncoding rna
- cell cycle arrest
- cell therapy
- rectal cancer
- smoking cessation
- pi k akt
- cerebral ischemia
- functional connectivity
- nucleic acid