Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene.

Yanming CaoBin WangDing WangDongxiang ZhanCaiyuan MaiPeng WangQiushi WeiYamei LiuHaibin WangWei He Liangliang Xu

Published in: International journal of genomics (2019)

Our study demonstrated that DNA methylation influenced the transcriptional expression of SOST gene, which probably may play an important role in the pathogenesis of primary osteoporosis.

Keyphrases

dna methylation
genome wide
poor prognosis
gene expression
copy number
end stage renal disease
ejection fraction
bone mineral density
chronic kidney disease
postmenopausal women
peritoneal dialysis
transcription factor
prognostic factors
long non coding rna
patient reported outcomes
oxidative stress
hip fracture