Metabolic Modulation of Histone Acetylation Mediated by HMGCL Activates the FOXM1/β-catenin Pathway in Glioblastoma.
Yanfei SunGuangjing MuXuehai ZhangYibo WuShuai WangXu WangZhiwei XueChuanwei WangJilong LiuWenbo LiLin ZhangYunyun GuoFeihu ZhaoXuemeng LiuZhiyi XueYan ZhangShilei NiJian WangXingang LiMingzhi HanBin HuangPublished in: Neuro-oncology (2023)
Changes in acetyl-CoA levels induced by HMGCL altered H3K27ac modification, which triggers transcription of FOXM1 and β-catenin nuclear translocation. Targeting HMGCL by JIB-04 inhibited tumor growth, indicating that mediators of BCAA metabolism may serve as molecular targets for effective GBM treatment.