Metabolic Modulation of Histone Acetylation Mediated by HMGCL Activates the FOXM1/β-catenin Pathway in Glioblastoma.

Yanfei SunGuangjing MuXuehai ZhangYibo WuShuai WangXu WangZhiwei XueChuanwei WangJilong LiuWenbo LiLin ZhangYunyun GuoFeihu ZhaoXuemeng LiuZhiyi XueYan ZhangShilei NiJian WangXingang LiMingzhi HanBin Huang

Published in: Neuro-oncology (2023)

Changes in acetyl-CoA levels induced by HMGCL altered H3K27ac modification, which triggers transcription of FOXM1 and β-catenin nuclear translocation. Targeting HMGCL by JIB-04 inhibited tumor growth, indicating that mediators of BCAA metabolism may serve as molecular targets for effective GBM treatment.

Keyphrases

dna methylation
epithelial mesenchymal transition
cell proliferation
cancer therapy
fatty acid
gene expression
histone deacetylase
combination therapy