Glucagon-like peptide-1 receptor is expressed in human and rodent testis.
Rosario CaltabianoDaniele CondorelliSalvatore PanzaCarla BoitaniNicolò MussoDavor JežekLorenzo MemeoLorenzo ColarossiVittoria RagoValentina MularoniSaveria SpadolaRoberto CastiglioneMarta SantoroSaveria AquilaRosario D'AgataPublished in: Andrology (2020)
In our findings, a careful evaluation of human testicular tissues and rodent testis revealed Leydig cells as a potential target for GLP-1. Collectively, an effect of GLP-1R in Leydig cell function may be presumed although future studies are needed to ascertain the GLP-1R's role both in normal and tumor Leydig cells.