Glucagon-like peptide-1 receptor is expressed in human and rodent testis.

Rosario CaltabianoDaniele CondorelliSalvatore PanzaCarla BoitaniNicolò MussoDavor JežekLorenzo MemeoLorenzo ColarossiVittoria RagoValentina MularoniSaveria SpadolaRoberto CastiglioneMarta SantoroSaveria AquilaRosario D'Agata

Published in: Andrology (2020)

In our findings, a careful evaluation of human testicular tissues and rodent testis revealed Leydig cells as a potential target for GLP-1. Collectively, an effect of GLP-1R in Leydig cell function may be presumed although future studies are needed to ascertain the GLP-1R's role both in normal and tumor Leydig cells.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
gene expression
germ cell
endoplasmic reticulum stress
pluripotent stem cells
oxidative stress
signaling pathway
single cell
current status
binding protein