Genetic Evidence for Protective Effects of Angiotensin-Converting Enzyme Against Alzheimer Disease But Not Other Neurodegenerative Diseases in European Populations.

David K RyanVille KarhunenBowen SuMatthew TraylorTom G Richardson Stephen Burgess Joanna Tzoulaki Dipender Gill

Published in: Neurology. Genetics (2022)

Genetic evidence supports protective effects of cerebral ACE expression on AD, but not other neurodegenerative outcomes in people of European ancestry. Further work is required to investigate whether therapeutic inhibition of ACE increases risk of Alzheimer disease.

Keyphrases

angiotensin converting enzyme
angiotensin ii
mild cognitive impairment
genome wide
poor prognosis
copy number
subarachnoid hemorrhage
metabolic syndrome
adipose tissue
brain injury
long non coding rna
weight loss
genetic diversity