Effect of obesity and epicardial fat/fatty infiltration on electrical and structural remodeling associated with atrial fibrillation in a novel canine model of obesity and atrial fibrillation: A comparative study.
Naoto OtsukaYasuo OkumuraMasaru AraiSayaka KurokawaKoichi NagashimaRyuta WatanabeYuji WakamatsuSeina YagyuKimie OhkuboToshiko NakaiHiroyuki HaoRie TakahashiYoshiki TaniguchiYxin LiPublished in: Journal of cardiovascular electrophysiology (2021)
Vulnerability to AF was associated with increased LA pressure and increased epicardial fat/fatty infiltration in our Obese group, and with increased epicardial fat/fibrofatty infiltration in the RAP and Obese-RAP groups. These may explain the role of obesity/epicardial fat in the pathogenesis of AF.
Keyphrases
- adipose tissue
- atrial fibrillation
- weight loss
- insulin resistance
- metabolic syndrome
- type diabetes
- fatty acid
- high fat diet induced
- bariatric surgery
- weight gain
- oral anticoagulants
- catheter ablation
- direct oral anticoagulants
- left atrial
- left atrial appendage
- percutaneous coronary intervention
- climate change
- obese patients
- skeletal muscle
- venous thromboembolism
- acute coronary syndrome