Does urbanicity modify the relationship between a polygenic risk score for depression and mental health symptoms? Cross-sectional evidence from the observational HUNT Study in Norway.

Erik Reidar SundFrank J van LentheMauricio Avendano PabonParminder RainaSteinar Krokstad

Published in: Journal of epidemiology and community health (2020)

The PRS predicted small but significant odds of anxiety, comorbid anxiety and depression and mental distress, but we found no support for a differential effect of genetic propensity in urban and rural neighbourhoods for any of the outcomes.

Keyphrases

mental health
cross sectional
sleep quality
depressive symptoms
south africa
genome wide
mental illness
gene expression
physical activity
dna methylation
skeletal muscle
weight loss