Innovative Phosphorene Nanoplatform for Light Antimicrobial Therapy.
Elisa PassagliaAntonella SgarbossaPublished in: Pharmaceutics (2023)
Over the past few years, antibiotic resistance has reached global dimensions as a major threat to public health. Consequently, there is a pressing need to find effective alternative therapies and therapeutic agents to combat drug-resistant pathogens. Photodynamic therapy (PDT), largely employed as a clinical treatment for several malignant pathologies, has also gained importance as a promising antimicrobial approach. Antimicrobial PDT (aPDT) relies on the application of a photosensitizer able to produce singlet oxygen ( 1 O 2 ) or other cytotoxic reactive oxygen species (ROS) upon exposure to appropriate light, which leads to cell death after the induced photodamage. Among different types of 2D nanomaterials with antimicrobial properties, phosphorene, the exfoliated form of black phosphorus (bP), has the unique property intrinsic photoactivity exploitable for photothermal therapy (PTT) as well as for PDT against pathogenic bacteria.
Keyphrases
- photodynamic therapy
- drug resistant
- staphylococcus aureus
- cell death
- reactive oxygen species
- public health
- fluorescence imaging
- multidrug resistant
- acinetobacter baumannii
- gram negative
- cell proliferation
- oxidative stress
- risk assessment
- heavy metals
- cell cycle arrest
- antimicrobial resistance
- drug induced
- drug delivery
- endothelial cells
- cell therapy
- global health
- anti inflammatory