A First in Human Clinical Trial Assessing the Safety and Immunogenicity of Two Intradermally Delivered Enterotoxigenic Escherichia coli CFA/I Fimbrial Tip Adhesin Antigens with and without Heat-Labile Enterotoxin with Mutation LT(R192G).
Ramiro L GutiérrezMark S RiddleChad K PorterMilton MacielSteven T PooleRenee M LairdMichelle LaneGeorge W TurianskyAbel JarellStephen J SavarinoPublished in: Microorganisms (2023)
Both ETEC adhesin vaccine prototypes were safe and immunogenic when co-administered with mLT by the ID route. The observed immune responses induced with the high dose of dscCfaE and mLT warrant further assessment in a controlled human infection model.