Visible-Light-Induced Metal-/Photocatalyst-Free C-H Bond Imidation of Arenes.
Takahito KuribaraMasaya NakajimaTetsuhiro NemotoPublished in: Organic letters (2020)
In this study, a visible-light-induced intermolecular C-H bond imidation of arenes was achieved at ambient condition. By using simple phthalimide with (diacetoxyiodo)benzene and molecular iodine, direct metal-/photocatalyst-free C-N bond formation was achieved. The imidation protocol was designed by using time-dependent density functional theory calculations and experimentally demonstrated for 28 substrates with as high as 96% yield. Mechanistic studies indicated that radical-mediated aromatic substitution occurred via photolysis of N-iodophthalimide under visible-light irradiation.
Keyphrases
- visible light
- density functional theory
- molecular dynamics
- air pollution
- randomized controlled trial
- particulate matter
- high glucose
- transition metal
- diabetic rats
- magnetic resonance imaging
- molecular dynamics simulations
- single molecule
- computed tomography
- drug induced
- oxidative stress
- radiation therapy
- amino acid
- case control
- monte carlo
- dual energy