HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.
Timothy J HenrichHiroyu HatanoOliver BaconLouise E HoganRachel RutishauserAlison L HillMary F KearneyElizabeth M AndersonSusan P BuchbinderStephanie E CohenMohamed Abdel-MohsenChristopher W PohlmeyerRemi FromentinRebecca HohAlbert Y LiuJoseph M McCuneJonathan SpindlerKelly A Metcalf PateKristen S HobbsCassandra ThanhErica A GibsonDaniel R KuritzkesRobert F SilicianoRichard W PriceDouglas D RichmanNicolas ChomontJanet M SilicianoJohn W MellorsSteven A YuklJoel N BlanksonTeri LieglerSteven G DeeksPublished in: PLoS medicine (2017)
We report HIV relapse despite initiation of ART at one of the earliest stages of acute HIV infection possible. Near complete or complete loss of detectable HIV in blood and tissues did not lead to indefinite ART-free HIV remission. However, the small numbers of latently infected cells in individuals treated during hyperacute infection may be associated with prolonged ART-free remission.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- liver failure
- induced apoptosis
- gene expression
- drug induced
- oxidative stress
- aortic dissection
- intensive care unit
- cell proliferation
- disease activity
- systemic lupus erythematosus
- cell cycle arrest
- signaling pathway
- rheumatoid arthritis
- newly diagnosed
- ulcerative colitis
- mechanical ventilation
- pi k akt