Elevated serum Neurofilament Light chain (NfL) as a potential biomarker of neurological involvement in Myotonic Dystrophy type 1 (DM1).

Tommaso Filippo NicolettiSalvatore RossiMaria Gabriella VitaAlessia PernaGisella GuerreraFederica LinoChiara IacovelliDaniele Di NataleAnna ModoniLuca BattistiniGabriella Silvestri

Published in: Journal of neurology (2022)

Our findings support serum NfL as a potential biomarker of CNS damage in DM1, which deserves further evaluation on larger cross-sectional and longitudinal studies to test its ability in assessing brain disease severity and/or progression.

Keyphrases

cross sectional
cerebral ischemia
resting state
early onset
blood brain barrier
cerebrospinal fluid
type diabetes
adipose tissue
functional connectivity
metabolic syndrome
skeletal muscle