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Impact of Ethnicity on Antiplatelet Treatment Regimens for Bleeding Reduction in Acute Coronary Syndromes: A Systematic Review and Pre-specified Subgroup Meta-analysis.

Mattia GalliRenzo LaboranteGiovanni OcchipintiAndea ZitoLuigi SpadaforaGiuseppe Biondi-ZoccaiRoberto NerlaFausto CastriotaDomenico D'AmarioDavide CapodannoYoung Hoon JeongTakeshi KimuraRoxana MehranDominick J Angiolillo
Published in: European heart journal. Cardiovascular pharmacotherapy (2023)
The majority of BRATs are associated with reduced bleeding without any trade-off in hard ischemic endpoints regardless of ethnicity. However, the supporting evidence and relative safety profiles of different BRATs might be significantly affected by ethnicity, which should be taken into account in clinical practice. Study registration This study is registered in PROSPERO (CRD42023416710).
Keyphrases
  • systematic review
  • acute coronary syndrome
  • clinical practice
  • atrial fibrillation
  • randomized controlled trial
  • oxidative stress
  • percutaneous coronary intervention
  • combination therapy
  • smoking cessation
  • phase iii