PECAM-1 Is Down-Regulated in γδT Cells during Remission, but Up-Regulated in Relapse of Multiple Sclerosis.
Michał Konrad ZarobkiewiczIzabela Morawska-MichalskaAgnieszka Bojarska-JunakPaweł HalczukJacek RolinskiAgnieszka A Bojarska-JunakPublished in: Journal of clinical medicine (2022)
Introduction . PECAM-1 and NKRP1A are both involved in the vascular transmigration of T lymphocytes. Vascular transmigration is a crucial process in multiple sclerosis pathogenesis. Methods and aim . The current paper presents an analysis of PECAM-1 and NKRP1A expression on γδ T cells. Expression of PECAM-1 and NKRP1A on subsets of γδ T cells was performed with flow cytometry. Results . Based on the flow cytometry data, PECAM1 was slightly differentially modulated on γδ T cells-it was up-regulated during relapse, but down-regulated during remission. Moreover, a significant downregulation of CD3 expression was noted on γδ T cells from MS patients, most notably during relapse. Conclusions . This may be a sign of the overall activation of γδ T cells in the course of multiple sclerosis.
Keyphrases
- multiple sclerosis
- flow cytometry
- poor prognosis
- transcription factor
- end stage renal disease
- white matter
- chronic kidney disease
- newly diagnosed
- binding protein
- mass spectrometry
- cell proliferation
- long non coding rna
- peritoneal dialysis
- disease activity
- signaling pathway
- rheumatoid arthritis
- ms ms
- electronic health record
- peripheral blood
- ulcerative colitis