Genetic variability in noncoding RNAs: involvement of miRNAs and long noncoding RNAs in osteoporosis pathogenesis.
Simona FittipaldiVirginia Veronica ViscontiUmberto TarantinoGiuseppe NovelliAnnalisa BottaPublished in: Epigenomics (2020)
The pathogenesis of osteoporosis is multifactorial and is the consequence of genetic, hormonal and lifestyle factors. Epigenetics, including noncoding RNA (ncRNA) deregulation, represents a link between susceptibility to develop the disease and environmental influences. The majority of studies investigated the expression of ncRNAs in osteoporosis patients; however, very little information is available on their genetic variability. In this review, we focus on two classes of ncRNAs: miRNAs and long noncoding RNAs (lncRNAs). We summarize recent findings on how polymorphisms in miRNAs and lncRNAs can perturb the lncRNA/miRNA/mRNA axis and may be involved in osteoporosis clinical outcome. We also provide a general overview on databases and bioinformatic tools useful for associating miRNAs and lncRNAs variability with complex genetic diseases.
Keyphrases
- postmenopausal women
- bone mineral density
- genome wide
- end stage renal disease
- copy number
- poor prognosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- metabolic syndrome
- healthcare
- dna methylation
- network analysis
- long non coding rna
- physical activity
- body composition
- patient reported outcomes
- weight loss
- high resolution
- peritoneal dialysis
- skeletal muscle
- human health
- genome wide analysis
- insulin resistance
- adipose tissue