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Evolution of the Innovative Therapies for Children With Cancer Consortium Trial Portfolio for Drug Development for Children With Cancer.

Francisco J Bautista SirventJaime VerduDidier FrappazAlba Rubio-San-SimónXavier PaolettiChristian Michel ZwaanMichela CasanovaLynley V MarshallFernando CarcellerFrançois DozCarole LecinseGilles VassalAndrew D J PearsonPamela R KearnsLucas Morenonull null
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
This study reports a shift in the paradigm of early drug development for childhood cancers, with more biologically relevant targets evaluated in biomarker-driven trials or in combination with other therapies and with more model-based or randomized designs and a greater focus on fulfilling regulatory requirements. Improvement of trial setup and recruitment could increase the number of patients benefiting from novel agents.
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