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Synthesis of Highly Functionalized N,N-Diarylamides by an Anodic C,N-Coupling Reaction.

Maurice DörrSebastian LipsCarlos Alberto Martínez-HuitleDieter SchollmeyerRobert FrankeSiegfried R Waldvogel
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
We report an innovative, sustainable and straightforward protocol for the synthesis of N,N-diarylamides equipped with nonprotected hydroxyl groups by using electrosynthesis. The concept allows the application of various substrates furnishing diarylamides with yields up to 57 % within a single and direct electrolytic protocol. The method is thereby easy to conduct in an undivided cell with constant current conditions offering a versatile and short-cut alternative to conventional pathways.
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