KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer.
Hong QiuVladimir MakarovJennifer K BolzeniusAngela HalsteadYvonne ParkerAllen WangGopakumar V IyerHannah C JohnsenDaniel KimVarna ThayaparanDaniel J LindnerGeorges-Pascal HaberAngela H TingBing RenTimothy A ChanVivek K AroraDavid B SolitByron H LeePublished in: Cancer research (2023)
A gain-of-function epigenetic switch that disrupts differentiation is triggered by inactivating KDM6A mutations in bladder cancer and can serve as a potential target for novel therapies.