A new cembranoid from the Red Sea soft coral Sarcophyton acutum .
Tarik A MohamedSeba M AbdelmawgoudAbdelhamid A HamdyMahmoud A A IbrahimAbdelsamed A ElshamyMontaser A M Al-HammadyHanaa A KassemMohamed-Elamir F HegazyNabil Mohamed SelimPublished in: Natural product research (2022)
The Red Sea soft coral Sarcophyton acutum ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A ( 1 ), along with six known metabolites have been isolated from S. acutum for the first time ( 2-7 ). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A ( 1 ) and gorgosterol ( 7 ) inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC 50 values of 35.5 and 44.0 μM, respectively.
Keyphrases
- cell proliferation
- endothelial cells
- papillary thyroid
- molecular docking
- oxidative stress
- ms ms
- breast cancer cells
- high resolution
- squamous cell
- cell cycle
- induced pluripotent stem cells
- pluripotent stem cells
- ionic liquid
- squamous cell carcinoma
- anti inflammatory
- lymph node metastasis
- young adults
- human health
- cell death
- climate change
- molecular dynamics simulations