From NOTIONs to nuances: TAVR and SAVR in low-risk patients.
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2024)
The NOTION trial, in this 10-year follow-up report, comprehensively compares transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low-risk patients. The study reveals similar outcomes in terms of mortality, stroke, and myocardial infarction. TAVR demonstrates advantages such as improved effective orifice area and transprosthetic gradients, along with reduced rates of new-onset atrial fibrillation. However, it is associated with higher rates of permanent pacemaker implantation and paravalvular leaks. Concerns exist regarding the generalizability of findings and unblinding during outcome assessments.
Keyphrases
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve
- ejection fraction
- aortic valve replacement
- end stage renal disease
- atrial fibrillation
- transcatheter aortic valve implantation
- chronic kidney disease
- newly diagnosed
- heart failure
- left ventricular
- randomized controlled trial
- clinical trial
- adipose tissue
- type diabetes
- acute coronary syndrome
- skeletal muscle
- venous thromboembolism
- phase ii
- direct oral anticoagulants
- brain injury
- open label
- vena cava