Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke.
Andrei V AlexandrovGeorgios TsivgoulisMartin KöhrmannAristeidis H KatsanosLauri SoinneAndrew D BarretoTravis RothlisbergerVijay K SharmaRobert MikulikKeith W MuirChristopher R LeviCarlos A MolinaMaher SaqqurDimitris MavridisTheodora PsaltopoulouMilan R VoskoJochen B FiebachPitchaiah MandavaThomas A KentAnne W AlexandrovPeter D Schellingernull nullPublished in: Therapeutic advances in neurological disorders (2019)
Our experience in CLOTBUST-ER indicates that increasing implementation of endovascular therapies across major academic stroke centers raises significant challenges for clinical trials aiming to test noninterventional or adjuvant reperfusion strategies.
Keyphrases
- acute ischemic stroke
- phase iii
- clinical trial
- double blind
- open label
- phase ii
- placebo controlled
- atrial fibrillation
- primary care
- healthcare
- early stage
- aortic dissection
- cerebral ischemia
- study protocol
- quality improvement
- estrogen receptor
- endoplasmic reticulum
- breast cancer cells
- acute myocardial infarction
- heart failure
- acute coronary syndrome
- randomized controlled trial
- left ventricular