Correction of depression-associated circadian rhythm abnormalities is associated with lithium response in bipolar disorder.
Monica FederoffMichael J McCarthyAmit AnandWade H BerrettiniHolli BertramAbesh BhattacharjeeCynthia V CalkinCarla ConroyWilliam H CoryellNicole D'ArcangeloAnna DeModenaCarrie FisherScott FeederNicole FrazierMark A FryeKeming GaoJulie GarnhamElliot S GershonNey Alliey-RodriguezKara GlazerFernando GoesToyomi KarbergGloria HarringtonPetter JakobsenMasoud KamaliMarisa KellySusan G LeckbandFalk LohoffAdam X MaihoferMelvin G McInnisFrancis MondimoreGunnar MorkenMichael C NealeKetil J OedegaardMegan RitcheyKelly RyanMartha SchinagleHelle SchoeyenCandice SchwebelMartha ShawPaul D ShillingClaire SlaneyAndrea StautlandBruce TarwaterJoseph R CalabreseMartin AldaCaroline M NievergeltPeter P ZandiJohn R KelsoePublished in: Bipolar disorders (2021)
Exposure to lithium is associated with reduced circadian disruption. Lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms. We conclude that stabilization of circadian rhythms may be an important feature of lithium's therapeutic effects. Clinical Trials Registry: NCT0127253.