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Polygenic risk scores associate with blood pressure traits across the lifespan.

Karsten ØvretveitEmma M L IngeströmMichail SpitierisVinicius TraganteKaitlin H WadeLaurent ThomasBrooke N WolfordUlrik WisløffDaniel F GudbjartssonHilma HólmKári StefánssonBen M BrumptonKristian Hveem
Published in: European journal of preventive cardiology (2023)
Genetic risk factors are associated with BP traits across the lifespan, beginning in the first years of life. Given the importance of exposure time in disease pathogenesis and the early rise in BP levels among those genetically susceptible, PRSs may help identify high-risk individuals prior to hypertension onset, facilitate primordial prevention, and reduce the burden of this public health challenge.
Keyphrases
  • blood pressure
  • risk factors
  • public health
  • genome wide
  • hypertensive patients
  • heart rate
  • dna methylation
  • blood glucose
  • global health
  • skeletal muscle
  • gene expression
  • weight loss