Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial.
Jason John LukeBenjamin E OnderdonkSandeep R BhaveTheodore KarrisonJeffrey M LemonsPaul J ChangYuanyuan ZhaTim CarllThomas KrauszLei HuangCarlos MartinezLinda A JanischRobyn D HseuJohn W MoroneyJyoti D PatelNikolai N KhodarevJoseph K SalamaPatrick A OttGini F FlemingThomas F GajewskiRalph R WeichselbaumSean P PitrodaSteven J ChmuraPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
In the context of SBRT+P, TMC independently correlates with OS. SBRT impacts intratumoral immune gene expression associated with TMC. Randomized trials are needed to validate these findings.