Acute coronary syndrome is associated with a substantial change in the platelet lipidome.

Tobias HarmAlexander BildKristina DittrichAndreas GoldschmiedJeremy Nestele Madhumita ChatterjeeXiaoqing FuKyra KolbTatsiana CastorOliver BorstTobias GeislerDominik RathMichael Lämmerhofer Meinrad Paul Gawaz

Published in: Cardiovascular research (2021)

Our results reveal that the platelet lipidome is altered in ACS and up-regulated lipids embody primarily glycerophospholipids. Alterations of the platelet lipidome, especially of medium chain lipids, may play a role in the pathophysiology of ACS.

Keyphrases

acute coronary syndrome
percutaneous coronary intervention
antiplatelet therapy
transcription factor
fatty acid
genome wide
dna methylation
gene expression
atrial fibrillation