Asthma prescribing according to Arg16Gly beta-2 genotype: a randomised trial in adolescents.

Tom J C Ruffles Christina J JonesColin PalmerStephen W Turner Jonathan GriggRoger TavendaleFiona HogarthPetra RauchhausKristina PilvinyteRomanie HannahHelen SmithRoberta LittlefordBrian LipworthSomnath Mukhopadhyay

Published in: The European respiratory journal (2021)

This is the first RCT demonstrating that genotype-driven asthma prescribing is associated with a significant improvement in a clinical outcome compared to standard care. Adolescents with the AA homozygous genotype benefited most. The potential role of such β2-adrenoceptor genotype directed therapy in younger and more severe childhood asthma warrants further exploration.

Keyphrases

chronic obstructive pulmonary disease
lung function
young adults
primary care
allergic rhinitis
physical activity
healthcare
palliative care
randomized controlled trial
emergency department
open label
quality improvement
study protocol
chronic pain
health insurance
risk assessment
human health
replacement therapy