KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
Karl A NathRaman Deep SinghAnthony J CroattAllan W AckermanJoseph P GrandeKhasayarsha KhazaieYuqing Eugene ChenJifeng ZhangPublished in: Kidney360 (2022)
Discovering new nephroprotectants may provide therapeutic strategies in AKI.This study provides the first evidence that KLF11, a member of the Krüppel-like factor (KLF) family of proteins, protects against AKI.In the absence of KLF11, exaggerated induction of endothelin-1 and IL-6 occurs after ischemic renal injury and may contribute to worse AKI.