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Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn's Disease.

Ingrid JurickovaBenjamin W DreskinElizabeth AngermanErin BonkowskiKentaro TominagaKentaro IwasawaTzipi BraunTakanori TakebeMichael A HelmrathYael HabermanJames M WellsLee A Denson
Published in: bioRxiv : the preprint server for biology (2024)
ETYA inhibits pro-fibrotic effects of LPS-primed macrophages upon co-cultured HIO. This model may be used in future untargeted screens for small molecules to treat refractory CD.
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