Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn's Disease.

Ingrid JurickovaBenjamin W DreskinElizabeth AngermanErin BonkowskiKentaro TominagaKentaro IwasawaTzipi BraunTakanori TakebeMichael A HelmrathYael HabermanJames M WellsLee A Denson

Published in: bioRxiv : the preprint server for biology (2024)

ETYA inhibits pro-fibrotic effects of LPS-primed macrophages upon co-cultured HIO. This model may be used in future untargeted screens for small molecules to treat refractory CD.

Keyphrases

endothelial cells
anti inflammatory
high glucose
systemic sclerosis
idiopathic pulmonary fibrosis
inflammatory response
mass spectrometry
adipose tissue
genome wide
high throughput
gene expression
drug induced
oxidative stress
high resolution
pluripotent stem cells