Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.
Erin ButlerBlake SchwettmannSophie GeboersGuiyang HaoJiwoong KimKien NhamXiankai SunTheodore W LaetschLin XuNoelle S WilliamsStephen X SkapekPublished in: Pediatric blood & cancer (2020)
The ability of MEK inhibitors to control MPNST growth cannot simply be predicted by serum drug levels or drug-induced changes in pERK expression. Tumor cell proliferation assessed by 18 F-FLT PET imaging might be useful as an early response marker to targeted therapies, including MEK inhibition, where a primary effect is cell-cycle arrest.
Keyphrases
- pi k akt
- cell cycle arrest
- pet imaging
- peripheral nerve
- cell proliferation
- signaling pathway
- cell death
- poor prognosis
- acute myeloid leukemia
- high resolution
- endoplasmic reticulum stress
- positron emission tomography
- tyrosine kinase
- cell cycle
- drug induced
- adverse drug
- cancer therapy
- computed tomography
- emergency department
- mass spectrometry
- endoplasmic reticulum
- long non coding rna