Lipid lowering and Alzheimer disease risk: A mendelian randomization study.

Dylan M WilliamsChris FinanAmand F SchmidtStephen BurgessAroon D Hingorani

Published in: Annals of neurology (2020)

We did not identify genetic support for the repurposing of statins, ezetimibe, or mipomersen for AD prevention. Notwithstanding caveats to this genetic evidence, pharmacovigilance for AD risk among users of PCSK9 inhibitors may be warranted. ANN NEUROL 2020;87:30-39.

Keyphrases

cardiovascular disease
copy number
emergency department
fatty acid
electronic health record