Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: A joint EORTC BTG and RANO effort.
Emilie Le RhunPatrick DevosSebastian WinklhoferHafida LmalemDieta BrandsmaPriya U KumthekarAntonella CastellanoAnnette CompterFrederic DhermainEnrico FranceschiPeter ForsythJulia FurtnerNorbert GalldiksJaime Gállego Pérez-LarrayaJens GemptElke HattingenJohann Martin HempelSlavka LukacovaGiuseppe MinnitiBarbara O'BrienTjeerd J PostmaPatrick RothRoberta RudàNiklas SchaeferNils O SchmidtTom Jan SnijdersSteffi ThustMartin van den BentAnouk van der HoornGuillaume VoginMarion SmitsJoerg C TonnKurt A JaeckleMatthias PreusserMichael GlantzPatrick Y WenMartin BendszusMichael WellerPublished in: Neuro-oncology (2022)
This study confirms the principle utility of the new scorecard, but also indicates the need for training of MRI assessment with a dedicated reviewer panel in clinical trials. Electronic case report forms with "blocking options" may be required to enforce completeness and quality of scoring.