Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression.
Ke CaiFeng WangHai-Qun ShiAn-Na ShenRui ZhaoHao-Ran GengJia-Quan LuYong-Hao GuiYan ShiJian-Yuan ZhaoPublished in: Cardiovascular research (2024)
Our study revealed that over-supplementation with FA during mouse pregnancy is detrimental to cardiac function with the decreased left ventricular ejection fraction in the offspring and provides insights into the mechanisms underlying the association between maternal FA status and health outcomes in the offspring.
Keyphrases
- ejection fraction
- aortic stenosis
- high fat diet
- pregnancy outcomes
- left ventricular
- birth weight
- poor prognosis
- transcatheter aortic valve replacement
- signaling pathway
- heart failure
- pregnant women
- preterm birth
- acute myocardial infarction
- single cell
- adipose tissue
- aortic valve
- type diabetes
- mitral valve
- hypertrophic cardiomyopathy
- coronary artery disease
- body mass index
- physical activity
- acute coronary syndrome
- cardiac resynchronization therapy
- atrial fibrillation