Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study.
Marija AngelovskiNikola Hadzi-PetrushevDino AtanasovAleksandar NikodinovskiVadim MitrokhinDimiter B AvtanskiMitko I MladenovPublished in: Life (Basel, Switzerland) (2022)
This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-κB activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summary, OTC treatments exerted cardioprotective effects against MI in vivo, mainly due to enhancing cardiac antioxidant activity.
Keyphrases
- high glucose
- acute myocardial infarction
- diabetic rats
- left ventricular
- oxidative stress
- signaling pathway
- single cell
- endothelial cells
- percutaneous coronary intervention
- nitric oxide
- immune response
- hydrogen peroxide
- cell therapy
- toll like receptor
- mesenchymal stem cells
- coronary artery disease
- inflammatory response
- fatty acid