Salivary alpha-1-antitrypsin and macrophage migration inhibitory factor may be potential prognostic biomarkers for oncologic treatment-induced severe oral mucositis.
Natália Rangel PalmierAdriana Franco Paes LemeTatiane De RossiGuilherme Pimentel TellesKarina Morais-FariaLuiz Paulo KowalskiGustavo Nader MartaThaís Bianca BrandãoPraveen R AranyCésar Augusto MiglioratiAlan Roger Dos Santos SilvaAna Carolina Prado RibeiroPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)
There is a correlation between the abundance of salivary A1AT and MIF and oncologic treatment-induced OM. The correlation of MIF expression with severe OM appears to be compatible with its physiological pro-inflammatory role. These results open up great possibilities for the use of salivary MIF and A1AT levels as prognostic markers for effective therapeutic interventions, such as photobiomodulation therapy, patient-controlled analgesia, or personalized medicaments.