A Sweet Approach to Heat Up Cancer Response to Immunotherapy.

Published in: Cancer discovery (2021)

Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies.See related article by Song et al., p. 1872.

Keyphrases

papillary thyroid
squamous cell
signaling pathway
poor prognosis
dna damage
squamous cell carcinoma
oxidative stress
young adults
binding protein