Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance.
Nannan SunChuangpeng ShenLei ZhangXiaojie WuYuanyuan YuXiaoying YangChen YangChong ZhongZhao GaoWei MiaoZehong YangWeihang GaoLing HuKevin WilliamsChanghui LiuYongsheng ChangYong GaoPublished in: Gut (2020)
These findings prove that a direct KLF16-PPARα pathway closely links hepatic lipid homeostasis and redox balance, whose dysfunction promotes insulin resistance and hepatic steatosis.