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Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling.

Evan A MulliganSusan J TudhopeJill E HunterArabella E G CliftSarah L ElliottGeoffrey P SummerfieldJonathan WallisChristopher J PepperBarabara DurkaczStephany VeugerElaine Willmore
Published in: Cancers (2023)
These data highlight a role for RelB in driving CLL cell tumour growth in a subset of patients and therefore strategies designed to inhibit non-canonical NF-κB signalling represent a novel approach that will have therapeutic benefit in CLL.
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