Expression and Activity of the NF-κB Subunits in Chronic Lymphocytic Leukaemia: A Role for RelB and Non-Canonical Signalling.
Evan A MulliganSusan J TudhopeJill E HunterArabella E G CliftSarah L ElliottGeoffrey P SummerfieldJonathan WallisChristopher J PepperBarabara DurkaczStephany VeugerElaine WillmorePublished in: Cancers (2023)
These data highlight a role for RelB in driving CLL cell tumour growth in a subset of patients and therefore strategies designed to inhibit non-canonical NF-κB signalling represent a novel approach that will have therapeutic benefit in CLL.
Keyphrases
- signaling pathway
- end stage renal disease
- lps induced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- oxidative stress
- pi k akt
- prognostic factors
- nuclear factor
- single cell
- stem cells
- big data
- patient reported outcomes
- mesenchymal stem cells
- inflammatory response
- cell proliferation
- machine learning
- binding protein
- deep learning
- artificial intelligence