SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction.
Jennifer GorwoodTina EjlalmaneshChristine BourgeoisMatthieu ManteconCindy RoseMichael AtlanDelphine DesjardinsRoger Le GrandBruno FèveOlivier LambotteJacqueline CapeauVeronique BereziatClaire LagathuPublished in: Cells (2020)
HIV/SIV promotes adipose tissue senescence, which in turn may alter adipocyte function and contribute to insulin resistance.
Keyphrases
- adipose tissue
- insulin resistance
- endothelial cells
- antiretroviral therapy
- hiv positive
- stem cells
- hiv testing
- hiv infected
- high fat diet
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- dna damage
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- stress induced
- south africa
- fluorescent probe
- mesenchymal stem cells
- fatty acid