BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia.
Ari SudwartsSupriya RameshaTianwen GaoMoorthi PonnusamyShuai WangMitchell HansenAlena KozlovaSara BitarafanPrateek KumarDavid Beaulieu-AbdelahadXiaolin ZhangLisa CollierCharles SzekeresLevi B WoodJubao DuanGopal ThinakaranSrikant RangarajuPublished in: Molecular neurodegeneration (2022)
Our convergent findings provide novel insights into microglial BIN1 function and demonstrate an essential role of microglial BIN1 in regulating brain inflammatory response and microglial phenotypic changes. Moreover, for the first time, our study shows a regulatory relationship between Bin1 and Ifitm3, two Alzheimer's disease-related genes in microglia. The requirement for BIN1 to regulate Ifitm3 upregulation during inflammation has important implications for inflammatory responses during the pathogenesis and progression of many neurodegenerative diseases.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- neuropathic pain
- toll like receptor
- transcription factor
- oxidative stress
- poor prognosis
- cell proliferation
- signaling pathway
- white matter
- multiple sclerosis
- cognitive decline
- spinal cord injury
- spinal cord
- long non coding rna
- subarachnoid hemorrhage
- blood brain barrier