UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR.
An-Jen ChiangGiou-Teng YiangKuan-Hao TsuiChung ChangYuan-Chin Ivan ChangLi-Wen ChenTsung-Hsien ChangJim Jinn-Chyuan SheuPublished in: Biomolecules (2020)
Cervical cancer is a common gynecological malignancy, accounting for 10% of all gynecological cancers. Recently, targeted therapy for cervical cancer has shown unprecedented advantages. Several studies have shown that ubiquitin conjugating enzyme E2 (UBE2C) is highly expressed in a series of tumors, and participates in the progression of these tumors. However, the possible impact of UBE2C on the progression of cervical squamous cell carcinoma (CESC) remains unclear. Here, we carried out tissue microarray analysis of paraffin-embedded tissues from 294 cervical cancer patients with FIGO/TNM cancer staging records. The results indicated that UBE2C was highly expressed in human CESC tissues and its expression was related to the clinical characteristics of CESC patients. Overexpression and knockdown of UBE2C enhanced and reduced cervical cancer cell proliferation, respectively, in vitro. Furthermore, in vivo experiments showed that UBE2C regulated the expression and activity of the mTOR/PI3K/AKT pathway. In summary, we confirmed that UBE2C is involved in the process of CESC and that UBE2C may represent a molecular target for CESC treatment.
Keyphrases
- cell proliferation
- squamous cell carcinoma
- endothelial cells
- poor prognosis
- end stage renal disease
- gene expression
- newly diagnosed
- ejection fraction
- chronic kidney disease
- transcription factor
- small molecule
- prognostic factors
- induced pluripotent stem cells
- signaling pathway
- peritoneal dialysis
- cancer therapy
- combination therapy
- smoking cessation
- binding protein
- drug induced
- locally advanced