Advanced therapies in orthopaedics.
Tobias WinklerSven GeisslerTazio MaleitzkeCarsten PerkaGeorg N DudaAlexander HildebrandtPublished in: EFORT open reviews (2024)
Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue to enable and promote physical activity. Despite advancements, the progress in developing advanced therapies in orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short of their expectations in musculoskeletal clinical trials. Researchers should focus on understanding the mechanism of action behind the investigated target before conducting clinical trials. Strategic research networks are needed that not only enhance scientific exchange among like-minded researchers but need to include early on commercial views, companies and venture perspectives, regulatory insights and reimbursement perspectives. Only in such collaborations essential roadblocks towards clinical trials and go-to-patients be overcome.
Keyphrases
- clinical trial
- physical activity
- end stage renal disease
- stem cells
- phase ii
- newly diagnosed
- chronic kidney disease
- mesenchymal stem cells
- open label
- palliative care
- peritoneal dialysis
- double blind
- body mass index
- prognostic factors
- study protocol
- phase iii
- randomized controlled trial
- mass spectrometry
- bone marrow
- patient reported
- patient reported outcomes
- high speed