Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity.

Jetta J Oppelaar Bart FerwerdaMohamed A RommanGhazalah N SahebdinAeilko H ZwindermanHenrike Galenkamp-van der Ploeg S Matthijs Boekholdt Bert-Jan H Van Den Born Rik H G Olde Engberink Liffert Vogt

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

exhibits higher BP in high sodium conditions when compared with low sodium conditions, whereas no differences were detected for the T allele. Concomitantly, both alleles demonstrate distinct expressions of D0S0, which, in turn, correlates with sodium-mediated BP elevation. These findings underscore the potential significance of genetic glycosaminoglycan variation in human BP regulation.

Keyphrases

endothelial cells
genome wide
copy number
risk assessment
pluripotent stem cells
climate change