Long Non-Coding RNAs Gene Variants as Molecular Markers for Diabetic Retinopathy Risk and Response to Anti-VEGF Therapy.

Hala M F Mohammad Ahmed A Abdelghany Essam Al Ageeli Shahad W Kattan Ranya Hassan Eman Ali Toraih Manal S Fawzy Naglaa Mokhtar

Published in: Pharmacogenomics and personalized medicine (2021)

The lncRNAs TUG1 (rs7284767G/A) and MIAT (rs1061540T/C) were associated with increased DR susceptibility and poor response to aflibercept treatment, while MALAT1 (rs3200401C/T) conferred protection to DR. These genetic determinants could be useful in DR risk stratification and pharmacogenetics after validation in large-scale studies.

Keyphrases

diabetic retinopathy
long non coding rna
editorial comment
copy number
genome wide
optical coherence tomography
poor prognosis
genome wide identification
vascular endothelial growth factor
dna methylation
gene expression
replacement therapy
combination therapy
single molecule