CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.
Lokesh A KalekarShirdi E SchmielSarada L NandiwadaWing Y LamLaura O BarsnessNa ZhangGretta L StriteskyDeepali MalhotraKristen E PaukenJonathan L LinehanM Gerard O'SullivanBrian T FifeKristin A HogquistMarc K JenkinsDaniel L MuellerPublished in: Nature immunology (2016)
The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-specific T cell antigen receptors, was also present in healthy hosts. Neuropilin-1 expression in anergic conventional CD4(+) T cells was associated with hypomethylation of genes related to thymic regulatory T cells (Treg cells), and this correlated with their ability to differentiate into Foxp3(+) Treg cells that suppressed immunopathology. Thus, our data suggest that not only is anergy induction important in preventing autoimmunity but also it generates the precursors for peripheral Treg cell differentiation.
Keyphrases
- regulatory t cells
- induced apoptosis
- cell cycle arrest
- dendritic cells
- poor prognosis
- oxidative stress
- cell death
- signaling pathway
- body mass index
- transcription factor
- endoplasmic reticulum stress
- high glucose
- machine learning
- mouse model
- chemotherapy induced
- gene expression
- drug induced
- celiac disease
- long non coding rna
- weight gain
- artificial intelligence
- binding protein
- gestational age