Characterization of myofiber-type-specific molecules using mass spectrometry imaging.

Naoko Goto-InoueMizuki MorisasaKazumasa MachidaYasuro FuruichiNobuharu L FujiiShinji MiuraTsukasa Mori

Published in: Rapid communications in mass spectrometry : RCM (2019)

Through MSI analyses, we performed a comprehensive survey to identify cell- and myofiber-specific molecular markers. In conclusion, we assigned muscle fiber Type I, IIa, and IIb-specific molecular ions at m/z 856.6, 872.6, and 683.8, respectively. These molecular markers might be useful for verifying changes that occur due to exercise and/or disease.

Keyphrases

mass spectrometry
high resolution
single molecule
skeletal muscle
physical activity
high intensity
liquid chromatography
cross sectional
mesenchymal stem cells
quantum dots
high performance liquid chromatography
resistance training
photodynamic therapy
body composition
fluorescence imaging