Variants on the UBE2L3-YDJC autoimmune disease risk haplotype increase UBE2L3 gene expression by modulating CTCF and YY1 binding.

Jaanam GopalakrishnanKandice L TessneerYao FuSatish PasulaRichard C PelikanJennifer A KellyGraham B WileyPatrick M Gaffney

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

The UBE2L3-YDJC autoimmune risk haplotype increases UBE2L3 expression through strengthening a YY1-mediated interaction between the UBE2L3 and YDJC promoters.

Keyphrases

gene expression
multiple sclerosis
poor prognosis
binding protein
copy number
drug induced
long non coding rna
transcription factor