Impact of Bone Marrow miR-21 Expression on Acute Myeloid Leukemia T Lymphocyte Fragility and Dysfunction.
Douâa Moussa AghaRedouane RouasMehdi NajarFatima BouhtitHussein Fayyad-KazanLaurence LagneauxDominique BronNathalie MeulemanPhilippe LewalleMakram MerimiPublished in: Cells (2020)
Our results demonstrate that miR-21 plays a significant role in AML T lymphocyte dysfunction and apoptosis. Targeting miR-21 may be a novel approach to restore the efficacy of the immune response against AML.
Keyphrases
- acute myeloid leukemia
- cell proliferation
- long non coding rna
- long noncoding rna
- bone marrow
- oxidative stress
- immune response
- poor prognosis
- allogeneic hematopoietic stem cell transplantation
- peripheral blood
- mesenchymal stem cells
- endoplasmic reticulum stress
- toll like receptor
- dendritic cells
- cancer therapy
- cell cycle arrest
- binding protein
- pi k akt
- signaling pathway
- inflammatory response